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GYOEDU Resident: Non-Epithelial Tumors of the Ovary

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Non-Epithelial Tumor Markers

Tumor Type Subtype Tumor Marker
Germ Cell Tumors Dysgerminoma LDH, hCG
Yolk Sac Tumor AFP
Embryonal Carcinoma AFP, hCG
Choriocarcinoma hCG
Teratoma (Immature) AFP (rarely elevated)
Mixed Germ Cell Tumor Depends on components (AFP, hCG)
Sex Cord-Stromal Tumors Granulosa Cell Tumor Inhibin, AMH, Estrogen
Sertoli-Leydig Tumor Androgens (Testosterone), Inhibin
Fibroma None (can be associated with Meigs syndrome)
Other Stromal Tumors Thecoma Estrogen
Gynandroblastoma Estrogen, Androgens
Miscellaneous Tumors Small Cell Carcinoma Hypercalcemia (PTH-rP elevated)

Highlighted are the clinically important tumor markers