Resident Assessment Quiz - Ovarian Cancer

Question 1: Which immunohistochemical marker is most helpful in supporting a diagnosis of a Müllerian-origin malignancy?

Question 2: Which of the following tumor characteristics best predicts a good response to platinum-based chemotherapy?

Question 3: A 65-year-old woman with no significant comorbidities presents with CT findings of a 10 cm ovarian mass, peritoneal implants, and pelvic lymphadenopathy. Her CA-125 is 3,200. Laparoscopic assessment reveals a Peritoneal Cancer Index (PCI) of 18 and Fagotti score of 9. Which of the following is the most appropriate management?

Question 4: Which of the following groups derives the greatest overall survival benefit from PARP inhibitor maintenance therapy?

Question 5: What is the approximate proportion of epithelial ovarian cancer patients with homologous recombination deficiency (HRD) based on current estimates?

Question 6: A 66-year-old woman with a history of stage IIIC high-grade serous ovarian cancer underwent optimal debulking and six cycles of carboplatin-paclitaxel. She remained disease-free for 18 months before recurrence with pelvic masses. She is asymptomatic and requests the least disruptive therapy. Which regimen is most appropriate to consider first?