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Cervical Cancer

GOG 92: Sedlis Criteria Study

Adjuvant pelvic radiotherapy significantly reduces the risk of cancer recurrence in women with Stage IB cervical cancer who have undergone radical hysterectomy and pelvic lymphadenectomy and possess specific high-risk factors. The treatment is associated with higher but acceptable morbidity.

SLND in Cervical Cancer

Landoni Trial: Radical Surgery versus Radiotherapy for Stage Ib-IIa Cervical Cancer

There is no clear treatment of choice for early-stage cervical carcinoma in terms of overall or disease-free survival. Treatment should be tailored to individual patient factors such as menopausal status, age, medical conditions, histological type, and cervical diameter to achieve the best outcomes

Early Stage Cervical Cancer

CONCERV Trial

Conservative surgery is feasible for select patients with early-stage, low-risk cervical cancer

SENTIREC: SLND in Cervical Cancer Study from Denmark

SENTICOL 2: Quality of Life After Sentinel Lymph Node Dissection in Cervical Cancer

SENTICOL 1: Sentinel LND in Cervical Cancer

KEYNOTE A18: Pembrolizumab Plus Chemoradiotherapy for High-Risk Locally Advanced Cervical Cancer

Pembrolizumab combined with chemoradiotherapy and then continued post-chemoradiotherapy demonstrates significant improvements in progression-free survival and OS compared to chemoradiotherapy alone

CALLA: Durvalumab versus placebo with chemoradiotherapy

Durvalumab concurrent with chemoradiotherapy was well tolerated but did not significantly improve progression-free survival compared to placebo in a biomarker-unselected all-comers population for locally advanced cervical cancer